Sequoia's father loved redwood trees and, after he was freed from the Matrix, he was devastated to learn that they were all extinct. In time he had a son and, out of his fondness for the now-gone trees, named him "Sequoia" - though everyone calls him "Seq" ("seek") for short.
60 years after Neo's death, Sequoia and the rest of the crew of the Mnemosyne rescued him from the Matrix.
Together with Neo, the crew enacted a plan from Sati to rescue Trinity from the Matrix as well. Despite multiple obstacles, they manage to succeed, with Neo and Trinity setting off to redesign the Matrix and free more minds.